BIORESORBABLE STENT WITH BENEFICIAL AGENT RESERVOIRS

摘要

A bioresorbable drug delivery stent includes a substantially cylindrical
expandable stent

formed of a bioresorbable material and a plurality of reservoirs or openings
formed in the stent
containing a beneficial agent matrix comprising a bioresorbable material and
drug. The
bioresorbable stent material can be a bioresorbable metal alloy, a
bioresorbable polymer, or
other biore- sorbable material which has sufficient structural integrity to
support a lumen,
such as a blood vessel lumen for a predetermined period of time. The
reservoirs containing the
beneficial agent matrix allow delivery of the beneficial agent, such as an
anti-restenotic drug, for
an administration period which is generally equal to or less than a time that
the bioresorbable
stent is retained in the lumen. The beneficial agent matrix may include one or
more
bioresorbable polymers in combination with one or more therapeutic agents or
drugs and the
structure of the beneficial agent matrix can be programmed to achieve a
desired release profile
for the drug(s) and sired administration period.