| 摘要 |
The present invention relates to pharmaceutical compositions comprising isolated binding members, such as antibodies and/or affibodies, capable of specifically binding a secretagogue, such as ghrelin or a ghrelin-like compound. In another aspect of the present invention, a kit and method are provided for detecting a disorder in appetite regulation in an individual. The present invention also relates to use of the isolated binding members disclosed herein for the production of a pharmaceutical composition, for the treatment of an individual in need thereof. There is further provided herein a method for treatment of an individual in need thereof, comprising administering to said individual an effective amount of one or more of the pharmaceutical compositions of the present invention. The present invention further relates to isolated nucleic acid molecules encoding at least a part of the binding members disclosed herein and vectors comprising said nucleic acid molecules. Host cells comprising said nucleic acids are also disclosed, and the present invention further relates to a cell line engineered to express one or more of the binding members disclosed herein. Furthermore, the present invention relates to cosmetic compositions comprising the binding members of the present invention and cosmetic methods using said cosmetic composition. |
