发明名称 |
THIADIAZOLIDINONES AS GSK-3 INHIBITORS |
摘要 |
Provided arc thiadiazolidinc compounds of formula I <CHEM> wherein R1 is an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a -C(O)- and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3 inhibitors and have improved bioavailability. They are useful for the treatment of GSK-3 mediated diseases, among others Alzheimer's disease, type II diabetes, depression and brain injury. |
申请公布号 |
CA2559740(A1) |
申请公布日期 |
2005.10.20 |
申请号 |
CA20052559740 |
申请日期 |
2005.04.04 |
申请人 |
NEUROPHARMA, S.A. |
发明人 |
DORRONSORO DIAZ, ISABEL;MARTINEZ GIL, ANA;PANIZO DEL PLIEGO, GEMA;PEREZ PUERTO, MARIA JOSE;MEDINA PADILLA, MIGUEL;ALONSO CASCON, MERCEDES;FUERTES HUERTA, ANA |
分类号 |
A61K31/433;A61P3/10;A61P25/28;C07D285/08;C07D417/04 |
主分类号 |
A61K31/433 |
代理机构 |
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代理人 |
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地址 |
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