4-hydroxypiperidine derivatives having analgesic activity

摘要

A compound represented by the following Formula (I): (wherein A represents oxygen atom or -NR³- (R³ represents hydrogen atom or lower alkyl group); R¹ represents nitro group, lower alkoxycarbonyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, unprotected or protected hydroxyl group, unprotected or protected carboxyl group, lower alkyl group substituted by unprotected or protected hydroxyl group, or tetrazolyl group; and R² represents hydrogen atom, cyano group or lower alkylsulfonyl group, provided that when A is -NR³-, it is excluded that R¹ represents unprotected or protected hydroxyl group or lower alkyl group substituted by unprotected or protected hydroxyl group) or its salt, and method for producing the compound, and a pharmaceutical composition containing the compound as active ingredient.