发明名称 |
New heterocyclic or benzenic derivatives of lipoic acid, their preparation and their use as medicaments |
摘要 |
A subject of the invention is new heterocyclic or benzenic derivatives comprising a lateral chain derived from lipoic acid, which have an inhibitory activity on NO-synthase enzymes producing nitrogen monoxide NO and/or are agents allowing the regeneration of antioxidants or entities trapping the reactive oxygen species (ROS) and which intervene in a more general manner in the redox status of thiol groups. A subject of the invention is also their preparation methods, the pharmaceutical preparations containing them and their use for therapeutic purposes, in particular their use as inhibitors of NO-synthases and/or as agents which intervene in a more general manner in the redox status of thiol groups.
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申请公布号 |
US2005227991(A1) |
申请公布日期 |
2005.10.13 |
申请号 |
US20050147561 |
申请日期 |
2005.06.08 |
申请人 |
HARNETT JEREMIAH;AUGUET MICHEL |
发明人 |
HARNETT JEREMIAH;AUGUET MICHEL |
分类号 |
A61K31/385;A61K31/4535;A61K31/496;A61P1/08;A61P3/04;A61P3/10;A61P7/02;A61P9/00;A61P9/10;A61P13/12;A61P15/08;A61P15/10;A61P25/00;A61P25/06;A61P25/08;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P25/36;A61P27/02;A61P29/00;A61P31/04;A61P35/00;A61P37/06;A61P43/00;C07D295/185;C07D333/38;C07D339/04;C07D409/12;C07D409/14;(IPC1-7):A61K31/496;C07D49/02 |
主分类号 |
A61K31/385 |
代理机构 |
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代理人 |
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地址 |
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