| 摘要 |
<p>An industrially usable process for producing a 1,2-cis-2-fluorocyclopropane-1-carboxylic ester. The process, which is for producing a compound represented by the following general formula (3): [Chemical formula 2] (wherein R<1> represents C1-8 alkyl, etc.), comprises reacting a compound represented by the following general formula (1): [Chemical formula 1] [wherein X<1> represents hydrogen, chlorine, bromine, or iodine and X<2> represents hydrogen, chlorine, bromine, or iodine, provided that not both of X<1> and X<2> are hydrogen; and R<1> is the same as defined above] with a reducing agent represented by the formula (2): M<1>BHmR<2>n (2-1) or M<2>(BHmR<2>n)2 (2-2) (wherein M<1> represents an alkali metal; M<2> represents an alkaline earth metal or zinc; R<2> represents hydrogen, etc.; and m is an integer of 1-4 and n is an integer of 0-3, provided that the sum of m and n is 4) in the presence of an aprotic polar solvent and a Lewis acid such as, e.g., a halide of an element selected among boron, magnesium, aluminum, etc.</p> |
