| 发明名称 |
Use of orthoesters for the synthesis of chiral acids in biocatalyzed irreversible esterification processes |
| 摘要 |
A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid, including an esterification reaction of the carboxylic acid in an organic solvent, in the presence of a stereoselective hydrolase, characterized in that an orthoester of the formula R<SUP>1</SUP>-C(OR<SUP>2</SUP>)<SUB>3</SUB>, in which R<SUP>1 </SUP>is selected from H and C<SUB>1</SUB>-C<SUB>4</SUB>alkyl and R<SUP>2 </SUP>is C<SUB>1</SUB>-C<SUB>8</SUB>alkyl or -CH<SUB>2</SUB>-C<SUB>6-10</SUB>aryl, is used as the esterification reactive.
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| 申请公布号 |
US6953678(B1) |
申请公布日期 |
2005.10.11 |
| 申请号 |
US20020048120 |
申请日期 |
2002.06.05 |
| 申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE |
发明人 |
MORRONE RAFFAELE;NICOLOSI GIOVANNI;PIATTELLI MARIO |
| 分类号 |
C12P7/40;C12P41/00;(IPC1-7):C12P17/00;C12N1/14;C12P7/62;C12P17/10 |
主分类号 |
C12P7/40 |
| 代理机构 |
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