发明名称 |
INHIBITOR FOR THE FORMATION OF gamma-SECRETASE COMPLEX |
摘要 |
<p>It is intended to provide an inhibitor for the formation of a gamma-secretase complex which comprises a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator as the active ingredient; and use of a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator for producing the same. It is also intended to provide a method of screening a substance having an effect of inhibiting the formation of an active complex of gamma-secretase which comprises assaying the activity of inhibiting cholesterol synthesis or quantifying cholesterol accumulated in lipid rafts in cells. It is also intended to provide a method of screening a cholesterol synthesis inhibitor, a protein geranylgeranylation regulator or an HMG-CoA reductase inhibitor which comprises assaying the effect of inhibiting the formation of an active complex of gamma-secretase. Moreover, it is intended to provide a method of screening an effect of a test substance on gamma-secretase which comprises measuring the distribution of constituents (niscastrin, APH-1, Pen-2 and so on) required by gamma-secretase for the formation of its active complex in cells.</p> |
申请公布号 |
WO2005063294(A8) |
申请公布日期 |
2005.10.06 |
申请号 |
WO2004JP19628 |
申请日期 |
2004.12.28 |
申请人 |
KOWA COMPANY, LTD.;NISSAN CHEMICAL INDUSTRIES, LTD.;URANO, YASUOMI;HAMAKUBO, TAKAO;KODAMA, TATSUHIKO |
发明人 |
URANO, YASUOMI;HAMAKUBO, TAKAO;KODAMA, TATSUHIKO |
分类号 |
A61K31/135;A61K31/35;A61K31/47;A61K31/724;A61K45/00;A61K45/06;A61P25/28;A61P43/00;C12Q1/00;(IPC1-7):A61K45/00 |
主分类号 |
A61K31/135 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|