Heterodimeric conjugates of neomycin-oxazolidinone, their preparation and their use

摘要

The present invention relates to novel oxazolidinone derivatives represented as following compound I and a process for the preparation thereof. The compounds of the present invention have wide antibacterial spectrums superior antibacterial activity and low toxicity. Therefore, it can be expected to use as novel antibacterial agent. wherein, R₁ is alkylcarboxyl group or -CH₂R₂ (wherein, R₂ is OH, argido group, -OR₃ (wherein, R₃ is C_1-4 alkyl, methansulfonyl, p-toluensulfonyl, carboxyl, C_1-4 alkylcarboxyl, C_1-4 alkylcarbonyl, benzyloxycarbonyl, or imidazolylcarbonyl), or -NHR₄).