TREATMENT OF NEURODEGENERATIVE DISEASES BY THE USE OF LAPTM4B

摘要

The invention relates to the use of a LAPTM4B-interacting molecule for the preparation of a pharmaceutical composition for the treatment of a neurogenerative disease. Hereby the LAPTM4B-interacting molecule is preferab ly an inhibitor of LAPTM4B and particularly it has the capacity to modulate the activity of gamma- secretase and/or beta-secretase. Furthermore the inventio n concerns a process for identifying a gamma-secretase and/or a beta-secretase modulator, comprising the following steps: a. identifying of a LAPTM4B- interacting molecule by determining whether a given test compound is a LAPTM 4B- interacting molecule, b. determining whether the LAPTM4B-interacting molecul e of step a) is capable of modulating gamma-secretase and/or beta-secretase activity.