A method for treating allergies using substituted pyrazoles

摘要

The use of a compound of formula (I), or a pharmaceutically acceptable salt, amide, or ester; or a stereoisomeric form, is described to be used in the preparation of a medicament for the treatment of an allergic condition. Ar2 is disclosed to be a monocyclic or bicyclic ring system, unsaturated, saturated or aromatic, optionally fused, optionally including from 1 to 5 heteroatom ring moieties independently selected from 0, S N, SO2, and C=O; said Ar2 ring system being optionally substituted; R5 and R6 are independently selected from hydrogen and C1-5 alkyl; R7 and R8 are independently hydrogen, C1-5 alkyl, C2-5 alkenyl, C1-5 alkoxy, C1-5 alkylthio, halogen, or a 4-7 membered carbocyclyl or heterocyclyl; alternatively, R7 and R8 can be taken together to form an optionally substituted 5- to 7- membered carbocyclic or heterocyclic ring, which ring may be unsaturated or aromatic, and may be optionally substituted; n is O,1,or 2; G is C3-6 alkenediyl or C3-6 alkanediyl, optionally substituted; Ar represents a monocyclic or bicyclic aryl or heteroaryl ring, optionally substituted; W represents 0, S, NR27, C=O, (C=O)NH, NH(C=0), CHR28, or a covalent bond; RZ is H or OH and the dashed line is absent; or Rz is absent where the dashed line is an sp2 bond.