CDC25 phosphatase inhibitors

摘要

Use of a compound with the general formula (I), or a pharmaceutically acceptable salt, is described to be for preparing a medicament intended to inhibit cdc25 phosphatases. A represents a radical of the formula (A1) or (A2). If A is an (A1) radical then two of the groups selected from the list consisting of R1, R2, R3, R4 and R5 are hydrogen atoms and the other three groups are independently chosen from the list consisting of a hydrogen atom, a halogen atom, an alkyl, hydroxyl, alkoky, alkylcarbonyloxy, alkylthio and NR6R7 radical. If A is an (A2) radical then either R11 and one R group selected from the list consisting of R13, R14 and R15 are hydroxyl radicals, R12 is selected from hydrogen and hydroxyl, and the remaining R groups, in (A2) are hydrogen. X is selected from the list consisting of a -(CH2)q-, -(CH2)q-NH- and a -CO-(CH2)r- radical, q being an integer from 1 to 6 and r an integer from 0 to 6; B is selected from the list consisting of a -CO-, -NH-CO-(CH2)n- and a -(CH2)p- radical, n being an integer from 0 to 3 and p being an integer from 0 to 1; W is a hydrogen atom or an alkyl radical; and either (i) or (ii) applies: (i) when X represents a -(CH2)q- or -CO-(CH2)r- radical, then Y represents a radical of formula (II) in which R19 is selected from the list consisting of -SO-2-NR23R24, -NH-SO2-R25 and a -O-P(O)(OR26)(OR27) radical; and R20 is selected from a hydrogen atom, a halogen atom, an alkyl, alkoxy and an alkylthio radical; (ii) when X represents a -(CH2)q-NH- radical, then Y is a -SO2-R30 radical in which R30 is selected from an alkyl, haloalkyl radical, substituted aryl, substituted heteroaryl, substituted aralkyl, substituted heteroaralkyl, aryl, heteroaryl, aralkyl and heteroaralkyl. A proviso explains that the B-N(W)-X-Y group is not the radical of formula (III). Also disclosed are processes for the preparation of certain compounds with general formula (I). Intended use is for the treatment of conditions such as tumorous and non-tumorous proliferative diseases, parasitic diseases and viral infections.