MONOCLONAL ANTIBODY AGAINST INTERLEUKIN-13 RECEPTOR ALPHA 1 (IL-13RA1)
摘要
<p>The present invention relates generally to antibodies that bind to the Interleukin-13 receptor.alpha.1 chain (IL-13R.alpha.1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R.alpha.1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R.alpha.1/ligand interaction is also provided.</p>
申请公布号
EP1576013(A2)
申请公布日期
2005.09.21
申请号
EP20030707913
申请日期
2003.03.21
申请人
AMRAD OPERATIONS PTY.,LTD.
发明人
DUNLOP, FELICITY, MEREDITH;BACA, MANUEL;NASH, ANDREW, DONALD;FABRI, LOUIS, JERRY;NICOLA, NICOS, A.;HILTON, DOUGLAS JAMES