METHOD OF PRODUCING MICROPARTICLES

摘要

Microparticles with a median particle diameter of 100µm or less are produced by means of a solvent evaporation method in which a bioactive and a vehicle in a solvent phase such as ethanol are emulsified in a non-solvent phase such as liquid paraffin and then the solvent is evaporated off. The emulsification is stabilised by employing a mixture of surfactants having a hydrophilic-lipophilic balance of up to 8.