PYRIMIDINE DERIVATIVE

摘要

A pyrimidine derivative simultaneously having 5-HT1A agonistic activity and 5- HT3 antagonistic activity and being useful for therapy, treatment, etc. for IBS and other diseases, represented by the formula: (I) wherein, the ring A is a carbocyclic group or heterocyclic group, X1 is a hydrogen atom, lower alky l, amino, etc., X2 is a hydrogen atom or lower alkyl, Y is a direct bond, or sulfur atom or nitrogen atom, n is an integer of 0 to 4, and Ar is a group o f the formula: or a salt of the pyrimidine derivative. Further, there is provided a method of treating IBS characterized in that 5-HT1A agonistic activity and 5-HT3 antagonistic activity are simultaneously exerted cooperatively in vivo by administering a 5-HT3 antagonist exhibiting an agonistic activity to 5-HT1A or by administering simultaneously, or in sequence, or at an interval a 5-HT1A agonist and a 5-HT3 antagonist.