发明名称 |
DNA vaccines encoding heat shock proteins |
摘要 |
The present invention is related to recombinant constructs encoding heat shock proteins or active fragments thereof that are effective in treating T cell mediated inflammatory autoimmune diseases by DNA vaccines. The treatment with the recombinant constructs of the present invention provides long-term expression of specific heat shock proteins for fragments thereof. In one embodiment, the present invention is related to a recombinant construct of a nucleic acid sequence encoding HSP60, HSP70 or HSP90. The present invention also is related to a recombinant construct of a nucleic acid sequence selected from amino acids 1-140 of HSP60, amino acids 130-260 of HSP60 and amino acids 31-50 of HSP60. Another aspect of the present invention is related to an active fragment of HSP60 corresponding to amino acids 31-50 of HSP60 effective in treating arthritis. |
申请公布号 |
US2005197306(A1) |
申请公布日期 |
2005.09.08 |
申请号 |
US20040994152 |
申请日期 |
2004.11.19 |
申请人 |
COHEN IRUN R.;QUINTANA FRANCISCO J.;CARMI PNINA;MOR FELIX |
发明人 |
COHEN IRUN R.;QUINTANA FRANCISCO J.;CARMI PNINA;MOR FELIX |
分类号 |
A61K38/17;A61K39/00;A61K48/00;(IPC1-7):A61K48/00 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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