发明名称 |
ALPHA ACYLOXYACETAMIDES FOR KALLIKREIN AND UROKINASE INHIBITION |
摘要 |
Disclosed herein is a compound represented by Structural Formula (I). R1 is a substituted or unsubstituted aryl group or alkyl group; R2 is a substituted or unsubstituted aryl group or cycloalkyl group; Ar is a substituted or unsubstituted aryl group; X is a -CH2-, -O-, -S- or -CO-, m is an integer from zero to two; n is an integer from 0-2 when X is -O-, -S- and 1-2 when X is -CH2- or -CO-. Also disclosed are methods of inhibiting kallikrein activity or urokinase activity in subject in need of such inhibition by administering a compound represented by Structural Formula (I). |
申请公布号 |
WO03101941(A3) |
申请公布日期 |
2005.09.01 |
申请号 |
WO2003US16665 |
申请日期 |
2003.05.28 |
申请人 |
GENZYME CORPORATION;STAVESKI, MARK, M.;SNEDDON, SCOTT, F. |
发明人 |
STAVESKI, MARK, M.;SNEDDON, SCOTT, F. |
分类号 |
C07C235/34;C07C235/36;C07C235/38;C07C237/30;C07C255/57;C07C323/25;C07D209/18;C07D215/12;C07D239/38;C07D317/58;C07D405/12;C07D495/04 |
主分类号 |
C07C235/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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