发明名称 |
VERFAHREN ZUR HERSTELLUNG VON 6-O-METHYLERYTHROMYCIN A UNTER VERWENDUNG VON 9-HYDROXYERYTHROMYCINDERATIVEN |
摘要 |
The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4''-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A. |
申请公布号 |
DE69825785(T2) |
申请公布日期 |
2005.08.18 |
申请号 |
DE1998625785T |
申请日期 |
1998.11.17 |
申请人 |
ABBOTT LABORATORIES, ABBOTT PARK |
发明人 |
KU, YI-YIN;RILEY, A.;LEE, C.;TIEN, J. |
分类号 |
C07H17/08;(IPC1-7):C07H17/08 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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