摘要 |
The invention provides novel isomers of dihydrotetrabenazine, namely 3,11b-cis-dihydrotetrabenazine isomers. Also provided are methods for making the isomers, pharmaceutical compositions containing them and their therapeutic uses, in particular the treatment of hyperkinetic movement disorders such as Huntington's disease, hemiballismus, senile chorea, tic, tardive dyskinesia and Tourette's syndrome, and the treatment of depression. The invention further provides synthetic intermediates for use in preparing the isomers of the invention. |