| 发明名称 |
CAMPTOTHECIN DERIVATIVES AND POLYMERIC CONJUGATES THEREOF. |
| 摘要 |
<p>Polymeric conjugates of camptothecin derivatives having increased circulating half-lives are disclosed. In preferred aspects, the E ring lactone of the camptothecin derivatives is opened and funtionalzed to allow attachment of a polymer such as PEG in the 17-or 20-position thereof. A representative example of such compound is (I) methods of preparing and using the same are also disclosed.</p> |
| 申请公布号 |
MXPA04011316(A) |
申请公布日期 |
2005.08.15 |
| 申请号 |
MX2004PA11316 |
申请日期 |
2003.05.16 |
| 申请人 |
ENZON PHARMACEUTICALS, INC. |
发明人 |
ZHAO, HONG |
| 分类号 |
C07D487/14;A61K31/4745;A61K31/77;A61K47/48;A61P35/00;A61P43/00;C07D471/14;C07D491/22;C07D519/00;C08G65/333;(IPC1-7):B32B27/32;B65D3/22;B65D65/40 |
主分类号 |
C07D487/14 |
| 代理机构 |
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