PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE HYDROXYMETHYLATED COMPOUNDS

摘要

[PROBLEMS] To provide catalysts permitting the progress of asymmetric hydroxymethylation with high asymmetric selectivity and processes for the production of optically active hydroxymethylated compounds with the catalysts. [MEANS FOR SOLVING PROBLEMS] Use of a catalyst obtained by mixing a chiral ligand (such as compound 4) with scandium triflate or the like in the reaction of silicon enolate with formaldehyde brings about optically active hydroxymethylated compounds with high asymmetric selectivity.