发明名称 |
METHOD FOR DEUTERATION OR TRITIATION OF HETEROCYCLIC RING |
摘要 |
<p>The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. <??>Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.</p> |
申请公布号 |
EP1561741(A1) |
申请公布日期 |
2005.08.10 |
申请号 |
EP20030811499 |
申请日期 |
2003.11.07 |
申请人 |
WAKO PURE CHEMICAL INDUSTRIES, LTD. |
发明人 |
ITO, NOBUHIRO;MAESAWA, TSUNEAKI;MUTO, KAZUSHIGE;HIROTA, KOSAKU;SAJIKI, HIRONAO |
分类号 |
C07B59/00;C07D209/20;C07D213/16;C07D231/12;C07D233/54;C07D233/58;C07D235/06;C07D239/54;C07D471/04;C07D473/30;C07H19/067;C07H19/167;(IPC1-7):C07B59/00;C07D209/08;C07D213/06;C07D235/08;C07D239/47;C07D473/34 |
主分类号 |
C07B59/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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