| 摘要 |
Monoclonal antibodies reactive with beta(1-3)-glucans are disclosed. More precisely, two monoclonal antibodies, B3B and A10A, reactive with beta(1-3)-glucan and/or beta(1-3) (1-6)-glucan associated epitopes in free, non-associated form, and/or in cell wall fragments of Candida and Cryptococcus are disclosed. Further, A10A is also reactive with a beta(1-6) (1-3)-glucan epitope present on the intact cell surface of C. albicans, C. parapsilosis, C. krusei, C. glabrata and/or C. neoformans. The antibodies can be used for the detection of free, cell wall associated, and/or cell surface associated beta(1-3) glucans utilizing immunoassays or immunohistology for the laboratory diagnosis of fungal infections. They may be used also for detection of airborn mould, or mould present in dust, water, or in any other component. |
