发明名称 |
INHIBITOR-RESISTANT HCV NS3 PROTEASE |
摘要 |
An inhibitor-resistant HCV NS3 protease is provided which is useful to screen for compounds having therapeutic value against drug resistant HCV strains. In particular, the inhibitor-resistant HCV NS3 protease comprises an amino acid sequence which is mutated in the substrate binding pocket thereof rendering the protease resistant to inhibitor. In a specific aspect of the present invention, at least one of the amino acids at position 155, 156 and 168 of the HCV NS3 protease is mutated to yield an inhibitor-resistant protease. |
申请公布号 |
EP1558730(A1) |
申请公布日期 |
2005.08.03 |
申请号 |
EP20030770808 |
申请日期 |
2003.10.24 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
KUKOLJ, GEORGE;LAGACE, LISETTE;MARQUIS, MARTIN;LAMARRE, DANIEL;PAUSE, ARNIM |
分类号 |
C12N9/50;(IPC1-7):C12N9/50;C12N15/10;C12Q1/68 |
主分类号 |
C12N9/50 |
代理机构 |
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