Method of administration of IGF-I

摘要

Disclosed is a method for administering insulin-like growth factor-I (IGF-I) to a non-human mammal so as to sustain its biological response in the treatment of a chronic disorder such as in the mammal comprising administering a therapeutically effective amount of IGF-I to the mammal to provide an exposure to IGF-I that is continuous or at least once a day consecutively over a period of days that provides the maximum biological response in the mammal, then discontinuing said administration by means of a continual lack of treatment or a lack of treatment for consecutive days over a period of days equal to or less than the number of days during which the IGF-I was previously administered, then repeating this pattern of administration and discontinuance of administration for as long as necessary to achieve or maintain sustained biological response in the mammal. Further disclosed is: the application of the method wherein the chronic disorder is chronic renal failure, diabetes, or an anabolic disorder, and, the method further comprising administering another drug to the mammal during the course of the treatment.