BENZIMIDAZOLE DERIVATIVES AND MEDICAL USES THEREOF

摘要

The invention provides benzimidazole derivatives represented by the general formula (I) or pharmacologically acceptable salts or prodrugs thereof which exhibit inhibitory activities against sodium-dependent nucleoside transporter 2 and are efficacious against diseases caused by abnormality in plasma uric acid level: (I) (wherein n is 1 or 2; R<1> and R<2> are each H, halogeno, cyano, optionally substituted alkyl, optionally substituted aryl, or the like; R<3> is H, halogeno, optionally substituted alkyl, or the like; R<4> and R<5> are each H, halogeno, OH, or the like; R<6> and R<X> are each H or OH; and R<Y> is F or OH). The compounds are useful in the prevention or treatment of gout, hyperuricemia, urolithiasis, hyperuricemic nephropathy, and so on.