摘要 |
CRF receptor antagonists are disclosed which have utility in the treatment o f a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure (I), including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, Y, Ar, and Het are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods f or use of the same.
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申请人 |
NEUROCRINE BIOSCIENCES, INC.;SB PHARMCO PUERTO RICO INC. |
发明人 |
WILLIAMS, JOHN P.;ZHANG, XIAHOU;LUO, ZHIYONG;SLEE, DEBORAH H.;TELLEW, JOHN EDWARD |