发明名称 MULTIPHASE ACTIVE INGREDIENT FORMULATION
摘要 The invention relates to a formulation having a plurality of phases containi ng active ingredients. Said formulation is characterised in that: it contains a first, innermost, finely distributed phase (I) consisting of active ingredients or an active ingredient solution, preferably some of the phase particles being surrounded by a barrier sheath (M); the formulation has a second, intermediate phase (II) that serves as a dispersant for the first, inner phase (I) and can also be dissolved in the active ingredient; and the formulation has a third, outer phase (III) that serves as a dispersant for t he second intermediate phase and can, in turn, be dissolved in the active ingredient and/or can be in the form of solid particles that can, in turn, b e surrounded by a barrier sheath. In this way, a plurality of biological activ e ingredients can be produced in the different phases in different concentrations and with a respectively controlled release rate in a single formulation. According to the invention, a mechanical stabilisation is achieved by solidifying the intermediate phase (II), enabling the formulatio n to be stable for a longer period of time even once it has been applied to a surface. Furthermore, by selecting a suitable solvent for the outer phase, t he formulations limit the release of the active ingredient from the innermost phase, and the capsules are not emptied and can thus be stored for a longer period of time.
申请公布号 CA2550351(A1) 申请公布日期 2005.07.14
申请号 CA20042550351 申请日期 2004.12.15
申请人 BAYER TECHNOLOGY SERVICES GMBH 发明人 HOFMANN, STEFAN;RUDHARDT, DANIEL;RIDDER, FRANK
分类号 A01N25/04;A01N25/28;A01N43/40;A01N49/00;A01N51/00;A01N53/00;A61K8/06;A61K9/10;A61K9/113;A61K9/40;A61K9/50;A61Q17/02 主分类号 A01N25/04
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