发明名称 |
METHOD OF REINFORCING ANTIBODY ACTIVITY |
摘要 |
<p>Antihuman Mpl antibody is obtained and purified. By using a genetic engineering technique, a single chain antibody of the antihuman Mpl antibody is further constructed. This antibody shows a high agonistic activity. This fact indicates that the activity of an antibody can be reinforced by binding two or more heavy chain variable domains to two or more light chain variable domains with the use of a linker to give a single chain polypeptide.</p> |
申请公布号 |
CA2548950(A1) |
申请公布日期 |
2005.06.23 |
申请号 |
CA20042548950 |
申请日期 |
2004.12.10 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TSUCHIYA, MASAYUKI;YABUTA, NAOHIRO;OHTOMO, TOSHIHIKO;TSUNODA, HIROYUKI |
分类号 |
C12N15/13;C07K16/00;C07K16/18;C07K16/46;C12P21/02;C12P21/08 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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