摘要 |
Monoclonal antibodies, including humanized antibodies, which bind acylated and unacylated human ghrelin are disclosed. An antibody of the invention can be a full- length antibody or an antigen-binding portion thereof. The antibodies of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention. |
申请人 |
ELI LILLY AND COMPANY;HEIMAN, MARK, LOUIS;KIKLY, KRISTINE, KAY;MANETTA, JOSEPH, VINCENT;WITCHER, DERRICK, RYAN |
发明人 |
HEIMAN, MARK, LOUIS;KIKLY, KRISTINE, KAY;MANETTA, JOSEPH, VINCENT;WITCHER, DERRICK, RYAN |