Angiogenesis inhibitors

摘要

Compounds represented by formula (I) below; a process for producing the compounds by culturing a microorganism belonging to the genus Aspergillus and isolating the above-mentioned compounds from the culture; an angiogenesis inhibitory agent containing as an active ingredient the compounds; and an Aspergillus sp. F-1491 (FERM BP-8288) strain capable of producing the compounds. In formula (I), R represents a methyl group or an ethyl group, R¹ represents a hydrogen atom, a chlorine atom, a hydroxyl group or a methoxy group, R² represents a hydroxyl group, or R¹ and R² taken together form an epoxy ring structure.