发明名称 |
THIADIAZOLES OR OXADIAZOLES AND THEIR USE AS INHIBITORS OF JAK PROTEIN KINASE |
摘要 |
The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and X are each independently oxygen or sulfur; A is nitrogen, CH, C-CN, or C-(C1-3 aliphatic); and R<1> and R<2> are taken together to form a ring. These compounds are useful as inhibitors or JAK kinases, particularly for the treatment of an autoimmune disease, a neurodegenerative disorder, or a hematologic malignancy.
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申请公布号 |
WO2004058753(A8) |
申请公布日期 |
2005.06.16 |
申请号 |
WO2003US14223 |
申请日期 |
2003.05.06 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;BEMIS, GUY, W.;HARBESON, SCOTT, L.;LEDEBOER, MARK |
发明人 |
BEMIS, GUY, W.;HARBESON, SCOTT, L.;LEDEBOER, MARK |
分类号 |
A61K31/4709;A61K31/517;A61K31/519;A61P37/00;C07D409/12;C07D409/14;C07D417/12;C07D417/14;C07D495/04;(IPC1-7):C07D417/12;C07D413/12;C07D413/14;C07D473/38;A61K31/470;A61K31/52 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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