METHODS FOR REDUCING BODY FAT USING VITAMIN D COMPOUNDS
摘要
A treatment for obesity and overweight comprises administering a vitamin D analog. The analog effectively inhibits an increase in body fat to animals at risk and decreases the basal fat content of animals. The treatment has a positive effect on the lean body component such that while there is an overall decrease in body weight, there is also a decrease in percent body fat. This decrease can be proportionally greater than the overall decrease in body weight. In addition, the treatment has a positive effect on bone turnover and osteogeneses making the vitamin D analog a beneficial treatment for the symptoms of menopause. Various exemplary embodiments of the treatment use the 2-alkylidene derivatives of vitamin D3, such as the 2-alkyliden-19-nor derivatives in both the R and S configurations at carbon-20.
申请公布号
WO2005051396(A2)
申请公布日期
2005.06.09
申请号
WO2004US39524
申请日期
2004.11.24
申请人
DELTANOID PHARMACEUTICALS, INC.;DELUCA, HECTOR, F.;PLUM, LORI, A.;KE, HAU, ZHE;BROWN, THOMAS, A.
发明人
DELUCA, HECTOR, F.;PLUM, LORI, A.;KE, HAU, ZHE;BROWN, THOMAS, A.