| 摘要 |
Use of an isolated polypeptide having one or more of at least one of the amino acid motifs (Glycine-Proline), (Proline-Glycine), (Glycine-Hydroxyproline) or (Hydroxyproline-Glycine) and consisting of from 2 to 100 amino acid residues, or use of a chemical compound comprising such a polypeptide associated with a non-polypeptide chemical entity, in the preparation of a medicament for the at least partial inhibition of a host site by a micro-organism. The invention most particularly relates to inhibition of infection of dentine by bacteria. The polypeptide preferably comprises at least one copy of the tripeptide motif (Glycine-Proline-X) where X is an amino acid or modified amino acid and where, in the case that two or more copies of the motif are present, X need not be identical in each copy of the motif. |
