Therapeutic substituted indazole derivatives

摘要

The invention provides a compound of Formula I Formula I wherein R¹ is aryl or heteroaryl each of which is optionally substituted with one or more of the following R³, -OR³, -OCOR³, -COOR³, -COR³, -CONR³R⁴, -NHCOR³, -NR³R⁴, -NHSO₂R³, -S₂R³, -SO₂NR³R⁴, -SR³, CN, halogeno or NO₂; R² is NO₂, NH₂, -NR⁵R⁶ or -NR⁶R⁷; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.