INTERSPERSED REPETITIVE ELEMENT RNAS AS SUBSTRATES, INHIBITORS AND DELIVERY VEHICLES FOR RNAI
摘要
The present invention provides methods for identifying druggable targets in assays that feature compositions, cells and/or organisms having interspersed repetitive element (IRE) RNAs and an RNA interference (RNAi) pathway. Methods for identifying therapeutic agents and creating vaccines are also featured. The invention further provides methods for inhibiting RNAi involving IRE RNAs or inhibitory derivatives thereof. The invention also provides compositions for delivering siRNA and miRNA molecules derived from IRE loci and methods of use thereof. Therapeutic methods are also featured.
申请公布号
WO2005047477(A2)
申请公布日期
2005.05.26
申请号
WO2004US37508
申请日期
2004.11.08
申请人
UNIVERSITY OF MASSACHUSETTS;KOWALIK, TIMOTHY, F.;STADLER, BRADFORD, M.