发明名称 |
HETEROCYCLIC BORONIC ACID COMPOUNDS |
摘要 |
<p>Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C (CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and Cr R<ii>, R<1>, R<1>, R<3>, R<4> and R<5> are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.</p> |
申请公布号 |
WO2005047297(A1) |
申请公布日期 |
2005.05.26 |
申请号 |
WO2004US37820 |
申请日期 |
2004.11.12 |
申请人 |
PHENOMIX CORPORATION;CAMPBELL, DAVID, ALAN;WINN, DAVID |
发明人 |
CAMPBELL, DAVID, ALAN;WINN, DAVID |
分类号 |
C07F5/02;(IPC1-7):C07F5/02;C07D403/12 |
主分类号 |
C07F5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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