发明名称 |
Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates |
摘要 |
The method for immune serum globulin purification relates to the purification of immune globulins from blood plasma with a high degree of efficiency and a high rate of recovery. The immune globulin source is Cohn's fraction I+II+III or II+III prepared from plasma or plasma intermediates by precipitation of the paste at pH 5.7 to 5.8 in the presence of 20% ethanol and 80% purified water. A glycine extraction is followed by an anion exchange chromatography column step to achieve a significantly high yield and high purity of the concentrated protein.
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申请公布号 |
US6893639(B2) |
申请公布日期 |
2005.05.17 |
申请号 |
US20010041950 |
申请日期 |
2001.10.19 |
申请人 |
HEMACARE CORPORATION |
发明人 |
LEVY JOSHUA;ROTHSTEIN FRED;SHIMIAEI BAHMAN |
分类号 |
C07K16/06;(IPC1-7):A61K39/395;C07K16/00 |
主分类号 |
C07K16/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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