发明名称 |
Chemotactic peptide antagonists for imaging sites of inflammation |
摘要 |
Radiopharmaceuticals comprising molecules that target to N-formyl-methionyl-leucyl-phenylalanine (fMLF) receptor on leukocytes in order to target sites of inflammation for diagnostic imaging are described. The targeting molecules are attached to capping groups that make the entire molecule either antagonists or weak agonists of fMLF receptor and therefore do not elicit a chemotactic response resulting in neutropenia. The preferred targeting molecule is ReO-Gly-lys(Dimethylgly-t-Butylgly-cys-gly)-glu-trp-phe-leu-nle-NHCOcyclopropyl. The invention also relates to the use of combinatorial chemistry to obtain preferred molecules that target sites of inflammation for diagnostic imaging.
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申请公布号 |
US2005100507(A1) |
申请公布日期 |
2005.05.12 |
申请号 |
US20040014403 |
申请日期 |
2004.12.16 |
申请人 |
BRACCO IMAGING S.P.A. |
发明人 |
ROE DAVID;RIBIC CHRISTINE M.;LAWRENCE BETTY C.;POLLOCK CATHERINE M.;POLLACK ALFRED |
分类号 |
A61K51/08;C07K7/02;C07K7/06;(IPC1-7):A61K51/00;G01N33/53;G01N33/543 |
主分类号 |
A61K51/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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