| 摘要 |
Human antibody fragments (Fab 14.6.19 and Fab 14.6.20) and human antibodies incorporating the same including polynucleotides and amino acids (SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5 AND SEQ ID NO:6) that identify them. Both Fabs are fully human, are affinity matured in vivo, are highly specific for breast and other cancers, and target an antigen that is immunogenic in vivo. Thus, each Fab may be a useful clinical reagent for diagnosis or therapy of breast and other cancers and may also lead to the discovery of a novel immunogenic and tumor specific cancer antigen. |
