发明名称 |
THERAPEUTIC USES OF CHEMOKINE VARIANTS |
摘要 |
Variants of homodimer-forming chemokines, such as human CCL2, having a single amino acid substitution in the dimerization interface that alters the pattern of hydrogen bonds and acting as an obligate monomer, can antagonize natural chemokines and have anti-inflammatory activity in vivo. These variants can be used as active ingredient in pharmaceutical compositions for the treatment of inflammatory, autoimmune, or infectious diseases. |
申请公布号 |
CA2536082(A1) |
申请公布日期 |
2005.04.28 |
申请号 |
CA20042536082 |
申请日期 |
2004.10.18 |
申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V |
发明人 |
PROUDFOOT, AMANDA;SHAW, JEFFREY;JOHNSON, ZOE |
分类号 |
C12N15/62;A61K38/19;A61P29/00;A61P31/00;A61P37/00;C07K14/52;C07K19/00;G01N33/68 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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