摘要 |
The present invention is directed to novel methods of treating or diagnosing a hyperproliferative disease or disorder in an patient, where the methods include administrating to the patient a binding molecule which binds to a cell surface-expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to the human LRRC15 protein. The present invention further provides a method of isolating and identifying cell surface expressed glycoproteins expressed in tumor or tumor associated tissues, where the method includes isolating desired glycoproteins via their affinity for specific lectins. |
申请人 |
BIOGEN IDEC MA INC.;KLOETZER, BILL;MCLACHLAN, KAREN;LABARRE, MIKE;FITCHETT, JONATHON;PEACH, ROBERT;SHESTOWSKY, BILL;GLASER, SCOTT |
发明人 |
KLOETZER, BILL;MCLACHLAN, KAREN;LABARRE, MIKE;FITCHETT, JONATHON;PEACH, ROBERT;SHESTOWSKY, BILL;GLASER, SCOTT |