发明名称 |
A PHARMACEUTICAL COMPOSITION FOR ANGIOTENSIN II-MEDIATED DISEASES |
摘要 |
This invention relates to a pharmaceutical composition of angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula (See formula I) wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, -O-, -S(O)m-(wherein m is 0, 1 or 2) or -N(R4)- (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.
|
申请公布号 |
CA2125251(C) |
申请公布日期 |
2005.04.26 |
申请号 |
CA19942125251 |
申请日期 |
1994.06.06 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
INADA, YOSHIYUKI;KUBO, KEIJI |
分类号 |
A61K31/495;A61K45/06;A61P9/12;(IPC1-7):A61K31/415 |
主分类号 |
A61K31/495 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|