发明名称 |
Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents. |
摘要 |
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents. |
申请公布号 |
ZA200400332(B) |
申请公布日期 |
2005.04.15 |
申请号 |
ZA20040000332 |
申请日期 |
2004.01.15 |
申请人 |
BRISTOL-MYERS SQUIBB PHARMA COMPANY |
发明人 |
DAVID NUGIEL;SUSAN DIMEO;EDDY YUE;DAVID CARINI;ANUP VIDWANS |
分类号 |
A61K31/416;A61K31/4439;A61K31/454;A61K31/496;A61K31/5377;A61K31/541;A61P31/04;A61P35/00;A61P43/00;C07D231/54;C07D401/04;C07D401/12;C07D403/04;C07D405/04;C07D405/12;C07D409/04;C07D409/12;C07D409/14 |
主分类号 |
A61K31/416 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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