发明名称 |
TARGETING ENZYMES OF THE tRNA SPLICING PATHWAY FOR IDENTIFICATION OF ANTI-FUNGAL AND/OR ANTI-PROLIFERATIVE MOLECULES |
摘要 |
The present invention relates to a method for screening and identifying compounds that modulate the activity of one or more components in the tRNA splicing pathway. In particular the invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease and/or tRNA splicing ligase. The invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease and/or animalia tRNA splicing ligase. The invention also provides assays for the identification of compounds that inhibit fungal tRNA splicing endonuclease and/or fungal tRNA splicing ligase. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer and/or fungal infections. |
申请公布号 |
WO2004087884(A3) |
申请公布日期 |
2005.04.14 |
申请号 |
WO2004US09590 |
申请日期 |
2004.03.26 |
申请人 |
PTC THERAPEUTICS, INC;TROTTA, CHRISTOPHER, R. |
发明人 |
TROTTA, CHRISTOPHER, R. |
分类号 |
A01N61/00;C12N;C12Q1/00;C12Q1/68;G01N33/566;G01N33/573;G01N33/574;(IPC1-7):A01N61/00 |
主分类号 |
A01N61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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