| 摘要 |
There is disclosed a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein R<1 >is aminosulfonyl, alkylsulfonyl, etc., R<2 >is hydrogen or halogen, R<3 >and R<4 >are hydrogen, halogen, alkyl or alkoxy, Ring A is benzene, pyridine, etc., and Ring Q is pyrazol, isoxazol, etc., and Ring Q and Ring A may be combined to each other to form a fused ring of the formula: where X is S or O, R<5 >is halogen, alkyl, etc., and R<3 >and R<4 >are the same as mentioned above, or a pharmaceutically acceptable salt thereof as an active ingredient.
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