9,10-alpha,alpha-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF

摘要

The present invention relates to new taxane analogs useful for the treatment of cancer as well as methods for producing the same. The chemical compounds according to the present invention have the general Formula (I) wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group ; R3 is hydroxyl or OP1; R4 and R5 are each hydroxyl or R7COO ; R6 is hydroxyl, OP2, R7COO, or an ether functionality ; R7 is an alkyl group, an olefinic group, or an aromatic group ; and P1 and P2 are each hydroxyl protecting groups. The chemical compounds of the present invention may particularly be 9, 10-alpha,alpha-OH taxane analogs that are formed by a process that begins with a standard taxane as the starting compound.