HIGH THROUGHPUT METHOD TO IDENTIFY LIGANDS FOR CELL ATTACHMENT
摘要
A high througtput method is provided for identifying agents capable of producing a desired biological response in whole cells. The method includes the steps of providing receptacles having a culture surface; placing differe nt mixtures of single agents into selective ones of the receptacles according t o a statistical design; and immobilizing the mixtures of single agents to the culture surface. The method further includes contacting the immobilized agen ts with the whole cells; and acquiring data which is indicative of a desired biological response in the contacted cells. The method also includes using statistical modeling of the acquired data to determine which mixtures of single agents and/or which single agents in these mixtures are affective in producing the desired biological response in the contacted cells.
申请公布号
CA2538010(A1)
申请公布日期
2005.03.31
申请号
CA20042538010
申请日期
2004.09.10
申请人
BECTON, DICKINSON AND COMPANY
发明人
HEIDARAN, MOHAMMAD A.;BODILY, CHRIS H.;LIEBMANN-VINSON, ANDREA;ROWLEY, JONATHAN A.