| 摘要 |
<p>The object of the present invention is to detect and select insulin-producing cells capable of proliferating, and further to differentiate/proliferate insulin-producing cells and precursory thereof, or cells related thereto. <??>The present invention was made by finding three species of novel genes by detecting genes specifically expressed in pancreases of PHHI patients which are regarded as a model of spontaneous proliferation of pancreatic beta cells, and searching for base sequence data bases. <??>According to the present invention, proliferating insulin-producing cells can be detected using these genes, gene products or gene sequences by, for example, Northern analysis or RT-PCR. Furthermore, these genes can be differentiated into insulin-producing cells by introducing these genes into appropriate cells in genetic engineering manner.</p> |
