发明名称 |
COMPUESTOS DERIVADOS DE 2-ALQUINIL O 2-ALQUENIL-5AMINO-PIRAZOLO-[4,3-E]-1,2,4-TRIAZOLO[1,5-]PIRIMIDINA; COMPOSICION FARMACEUTICA, Y USO EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL O UN ACCIDENTE CEREBROVASCULAR TAL COMO DEPRESION, |
摘要 |
Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4 </SUP>and R<SUP>5 </SUP>are H, alkyl or alkoxyalkyl; R<SUP>6 </SUP>is H, alkyl, hydroxyalkyl or -CH<SUB>2</SUB>F; R<SUP>7</SUP>, R<SUP>8 </SUP>and R<SUP>9 </SUP>are H, alkyl, alkoxy, alkylthio, alkoxyalkyl, halo or -CF<SUB>3</SUB>; and Z is optionally substituted aryl, heteroaryl or heteroaryl-alkyl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them. |
申请公布号 |
CL2004000847(A1) |
申请公布日期 |
2005.03.11 |
申请号 |
CL20040000847 |
申请日期 |
2004.04.21 |
申请人 |
SCHERING CORPORATION |
发明人 |
NEUSTADT BERNARD R.,BOYLE CRAIG D.,CHACKALAMANNILSAMUEL, HAO JINSONG, LIU HONG,SHAH UNMESH G.,STAMFORD ANDREW |
分类号 |
A61K31/519;A61P25/00;A61P25/16;C07D231/00;C07D239/00;C07D249/00;C07D487/14;(IPC1-7):A61K31/519 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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